Estrogen Heart Disease

Estrogen Heart Disease If you’re a woman in your forties, you’ve probably been considering hormone replacement therapy (HRT) for some time. As you approach the age of menopause (the average age at menopause is 51.4 years). You will start to take the problems of HRT more seriously.

If you’re going through menopause, is HRT suitable for you? A Family Favorite Just ten years ago, virtually all postmenopausal women were automatically prescribed estrogen or estrogen plus progestin, another female hormone. As a result, HRT has been the standard treatment for hot flashes, vaginal dryness, insomnia, and other menopausal symptoms.

Estrogens And Estrogen Receptors

While the E2 in eggs acts as a hormonal agent affecting distal tissues. An area of ​​the body other than ovarian or testicular production, E2 acts locally as a paracrine or endocrine agent in the tissues where it synthesizes. Therefore, an area of ​​the body other than the ovaries or testicles’ E2 production is essential as it remains the only source of endogenous E2 production in postmenopausal women and men.

In the genomic pathway, E2 binding triggers the intracellular localization of ERα and ERβ, which dimerize and enter the nucleus. In addition, E2 binds to the membrane-bound receptors ERα, ERβ, and GPR30 to rapidly activate nuclear transcription factors via the MAPK pathway.

While controversial, all three E2 receptors have to identify as functional and present in adult cardiomyocytes. The role of each ER and the mechanism by which it confers cardioprotection active investigation in various animal models.

Estrogen Heart Disease And The Cardiovascular System

Studies have shown estrogen affects almost every tissue or organ system, including the heart and blood vessels. A result of heart disease is the number one killer among women over age 65. It is an important issue. Women develop heart disease ten years later than men, but by age 65, their risk is equal to that of men.

When estrogen levels decline, LDL cholesterol (harmful) levels increase. HDL cholesterol (positive) decreases. Leading to the build-up of fat and cholesterol in the arteries, contributing to heart attack and stroke.

Review Of Recommendations

These were the first large-scale studies to investigate the cause and effect of heart disease and HRT to prevent osteoporosis and reduce the risk of colon cancer. Accordingly, the American Heart Association. In addition the United States Food and Drug Administration have developed new guidelines on HRT use: HRT should not be used to prevent heart attack or stroke.

The use of HRT for other concerns, e.g, B. the prevention of osteoporosis, must be carefully considered, and the risks should think about against the benefits. Long-term use did not recommend because the risk of heart attack, stroke, and breast cancer increases with the duration of HRT use.

HRT After Menopause, Estrogen Heart Disease

 

How Common Is Heart Disease In Women?

Cardiovascular disease is NOT just a male disease. Cardiovascular disease is a cause of death for women over 25 in the United States, regardless of race or ethnicity. As a woman reaches age 50 (about natural menopause), her risk of heart disease increases. Young women with premature or surgical menopause are also at higher risk of heart disease. Particularly when combined with other risk factors such as high-density lipoprotein (cholesterol) cholesterol, sometimes called “good” cholesterol;

• cholesterol
• obesity
• Physical inactivity
• Family history of heart disease.

What is Menopause?

Menopause is a typical phase in a woman’s life. The term menopause broadly describes any changes a woman experiences before or after her period ends. As menopause approaches, the ovaries gradually produce less estrogen (the female hormone), causing menses and other physical changes. The most common climacteric symptoms are hot flashes, night sweats, emotional changes, and vaginal changes (dryness and atrophy or thinning of the vaginal walls).

Technically, climacteric is the end of a woman’s reproductive cycle, when the ovaries stop producing eggs, and the woman has her last period. The diagnosis of menopause is only confirmed when a woman has not had a period for six to 12 consecutive months. Menopause usually occurs naturally in women between the ages of 45 and 55. However, estrogen loss can also occur when the ovaries remove during surgery or when a woman enters early menopause.

How Is Heart Disease Associated With Menopause

Estrogen helps a young woman’s body protect her from heart disease—changes in blood vessel walls that increase the likelihood of atherosclerotic plaque and blood clots forming. In addition, there are changes in blood levels of lipids (fats) and Increased fibrinogen (a substance in the blood that helps blood to clot). High levels of fibrinogen in the blood are associated with heart disease and stroke.

What Can Be Done To Reduce Heart Disease Risk In Postmenopausal Women?

Recent studies in women, such as the Heart and Estrogen/Progestin Replacement Study (HERS) and the Women’s Health Initiative (WHI), have shown that the overall health risks outweigh the benefits of HRT. For example, women participating in WHI had an increased risk of breast cancer. Coronary artery disease (including nonfatal heart attacks), stroke, blood clots, and gallbladder disease.

However, based on recent clinical trial results, the American Heart Association advises against women taking postmenopausal hormone therapy (PHT), formerly known as hormone replacement therapy or (HRT), to decrease the risk of chest pains, artery disease, or stroke.”

What Exactly Is Hormone Replacement Therapy?

Hormone replacement therapy is a treatment program in which a woman takes estrogen with or without progestin (synthetic progesterone). However, progestin is usually advice with estrogen to decrease the risk of uterine cancer in women with a uterus.

What Are The Benefits Of HRT?

Benefits of HRT for postmenopausal women include Increased elasticity in blood vessels, causing them to dilate (dilate) and allowing blood to flow throughout the body. Short-term relief of menopausal symptoms. Such as hot flashes and mood swings and vaginal dryness, dry skin, insomnia, and irritable bladder symptoms Reduced risk of osteoporosis and fractures (broken bones) Reduction of colon cancer Potential reduction in Alzheimer’s Potential improvement in blood sugar

Is HRT Safe

Short-term HRT is safe for most postmenopausal women who are using HRT for the relief of symptoms. However, you should discuss your medical record with your doctor before prescribing any HRT. Then, you and your doctor can decide if you have a health problem or an inherent health risk that makes it unsafe for you to take HRT.

For example, HRT is not recommended in women with a History of heart attack or stroke and increased risk of vascular disease, unexplained vaginal bleeding, active or previous breast cancer, fibrocystic breast disease, active liver endometrial cancer breast disease, gallbladder high risk of blood clots.

What Are The Risks Of HRT?

The health risks of HRT include an Increased risk of endometrial cancer (only when estrogen take without progestin). It is not trouble for a female who removes the uterus. Increases risk of breast cancer with long-term use increases the risk of cardiovascular disease. Including heart attack, blood clots, and stroke, especially during the first year of service in susceptible women.

What Are The Side Effects Of HRT?

About 5 to 10 percent of women with HRT have side effects, including breast affection, fluid retention, and mood swings. In most cases, these complications are mild and do not need the female to finish HRT therapy.

If you have a bothersome complication from HRT, talk to your doctor. They can often reduce these side effects by changing the type and dosage of estrogen and Prometrium.

If you have a uterus and take Prometrium, monthly vaginal bleeding will likely occur. Discuss this with your healthcare provider if it bothers you to have your monthly menstrual cycle.

Is HRT The Same As Birth Control? In Estrogen Heart Disease

No. Although women taking birth control pills also take estrogen and progestin, the result differs. The female who takes birth control pills has not been through climacteric and needs higher levels of hormones to prevent exhaustion. HRT is not a sufficiently high strength to stop ovulation.

After the end of the mensuration cycle, estrogen levels are low, and HRT is uses at a low dose to replace  hormone levels to a common level.

How Do I Chose If HRT Is Right For Me?

The best applicant for HRT must periodically evaluate if HRT is the proper treatment for them. You and your health maintenance provider should discuss your medical history, risk factors, and how HRT can address your needs.

Conclusion

Women who participated in the WHI had an increased risk of breast cancer, coronary artery disease (including nonfatal heart attacks), stroke, blood clots, and gallbladder disease. However, based on recent clinical studies. The American Heart Association advises against women taking postmenopausal hormone therapy (PHT), formerly known as hormone replacement therapy (HRT), to reduce the risk of chest pain, arterial disease, or stroke.

The increased risk of breast cancer with long-term use of increases the risk of cardiovascular disease. Including heart attack, blood clots, and stroke, particularly in the first year of service in susceptible women.